PDBsum entry 8uh3

Signaling protein

PDB id: 8uh3

Contents

Protein chains

333 a.a.

217 a.a.

269 a.a.

229 a.a.

50 a.a.

Ligands

CLR ×4

WOQ

Waters ×1

PDB id:

8uh3

Name:

Signaling protein

Title:

Serotonin 1e receptor (5-ht1er)-gi1 complex bound with setiptiline

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: gnai1. Gene: htr1e.

Authors:

D.Wacker,A.K.Parpounas,A.L.Warren,G.Zilberg

Key ref:

D.Wacker et al. Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5- And 5-Ht1fr. To be published, . PubMed id: 38630816

Date:

06-Oct-23 Release date: 01-May-24

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 333 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.

Protein chain

P28566  (5HT1E_HUMAN) -  5-hydroxytryptamine receptor 1E from Homo sapiens

Seq: 365 a.a.

Struc: 269 a.a.*

Protein chain

No UniProt id for this chain

Struc: 229 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 50 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????