PDBsum entry 8ugy

Signaling protein

PDB id: 8ugy

Contents

Protein chains

217 a.a.

333 a.a.

50 a.a.

264 a.a.

Ligands

CLR ×5

WRU

Waters ×1

PDB id:

8ugy

Name:

Signaling protein

Title:

Serotonin 1e receptor (5-ht1er)-gi1 complex bound with mianserin

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: gnb1. Gene: gng2.

Authors:

G.Zilberg,A.L.Warren,D.Wacker

Key ref:

G.Zilberg et al. Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5- And 5-Ht1fr. To be published, . PubMed id: 38630816

Date:

06-Oct-23 Release date: 01-May-24

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 333 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 50 a.a.

Protein chain

P28566  (5HT1E_HUMAN) -  5-hydroxytryptamine receptor 1E from Homo sapiens

Seq: 365 a.a.

Struc: 264 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????