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PDBsum entry 8u4s
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protein ligands Protein-protein interface(s) links
Signaling protein/immune system PDB id
8u4s

 

 

 

 

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Contents
Protein chains
110 a.a.
125 a.a.
284 a.a.
Ligands
CLR ×6
D21 ×3
PDB id:
8u4s
Name: Signaling protein/immune system
Title: Structure of trimeric cxcr4 in complex with regn7663 fab
Structure: Regn7663 fab light chain. Chain: l, a, e. Engineered: yes. Regn7663 fab heavy chain. Chain: h, b, f. Engineered: yes. C-x-c chemokine receptor type 4. Chain: r, c, g. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: cxcr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Authors: K.Saotome,L.L.Mcgoldrick,M.C.Franklin
Key ref: K.Saotome et al. Structural insights into cxcr4 modulation and oligomerization. Biorxiv, . PubMed id: 39313635
Date:
11-Sep-23     Release date:   13-Mar-24    
PROCHECK
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 Headers
 References

Protein chains
No UniProt id for this chain
Struc: 110 a.a.
Protein chains
No UniProt id for this chain
Struc: 125 a.a.
Protein chains
Pfam   ArchSchema ?
P42212  (GFP_AEQVI) -  Green fluorescent protein from Aequorea victoria
Seq:
Struc: 		238 a.a.
284 a.a.*
Protein chains
Pfam   ArchSchema ?
P61073  (CXCR4_HUMAN) -  C-X-C chemokine receptor type 4 from Homo sapiens
Seq:
Struc: 		352 a.a.
284 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 70 residue positions (black crosses)

 

 

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