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PDBsum entry 8u4r
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protein ligands Protein-protein interface(s) links
Signaling protein/immune system PDB id
8u4r

 

 

 

 

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Contents
Protein chains
111 a.a.
125 a.a.
277 a.a.
Ligands
CLR
PDB id:
8u4r
Name: Signaling protein/immune system
Title: Structure of regn7663-fab bound cxcr4
Structure: Regn7663 fab light chain. Chain: l. Engineered: yes. Regn7663 fab heavy chain. Chain: h. Engineered: yes. C-x-c chemokine receptor type 4. Chain: r. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: cxcr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Authors: K.Saotome,L.L.Mcgoldrick,M.C.Franklin
Key ref: K.Saotome et al. Structural insights into cxcr4 modulation and oligomerization. Biorxiv, . PubMed id: 39313635
Date:
11-Sep-23     Release date:   13-Mar-24    
PROCHECK
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 Headers
 References

Protein chain
No UniProt id for this chain
Struc: 111 a.a.
Protein chain
No UniProt id for this chain
Struc: 125 a.a.
Protein chain
Pfam   ArchSchema ?
P42212  (GFP_AEQVI) -  Green fluorescent protein from Aequorea victoria
Seq:
Struc: 		238 a.a.
277 a.a.*
Protein chain
Pfam   ArchSchema ?
P61073  (CXCR4_HUMAN) -  C-X-C chemokine receptor type 4 from Homo sapiens
Seq:
Struc: 		352 a.a.
277 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 126 residue positions (black crosses)

 

 

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