PDBsum entry 8u02

Membrane protein

PDB id: 8u02

Contents

Protein chains

272 a.a.

344 a.a.

339 a.a.

58 a.a.

Ligands

LDP

PDB id:

8u02

Name:

Membrane protein

Title:

Cryoem structure of d2 dopamine receptor in complex with goa ke mutant and dopamine

Structure:

D(2) dopamine receptor. Chain: r. Engineered: yes. Guanine nucleotide-binding protein g(o) subunit alpha. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: a.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: drd2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnao1. Gene: gnb1. Gene: gng2.

Authors:

B.E.Krumm,N.J.Kapolka,J.F.Fay,B.L.Roth

Key ref:

K.M.Knight et al. (2024). A neurodevelopmental disorder mutation locks g protei the transitory pre-Activated state.. Nat commun, 15, 6643. PubMed id: 39103320

Date:

28-Aug-23 Release date: 21-Aug-24

Protein chain

P14416  (DRD2_HUMAN) -  D(2) dopamine receptor from Homo sapiens

Seq: 443 a.a.

Struc: 272 a.a.

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 344 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 58 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????