PDBsum entry 8tyw

Membrane protein

PDB id: 8tyw

Contents

Protein chains

264 a.a.

339 a.a.

237 a.a.

58 a.a.

128 a.a.

PDB id:

8tyw

Name:

Membrane protein

Title:

Cryo-em structure of gpr6-gs-nb35 complex

Structure:

G-protein coupled receptor 6. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gpr6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gnas, gnas1, gsp. Gene: gng2.

Authors:

M.Barekatain,L.C.Johansson,J.H.Lam,A.V.Sadybekov,G.W.Han,P.Popov, J.Russo,J.Bliesath,N.Brice,M.Beresford,L.Carlson,K.S.Saikatendu, H.Sun,S.Murphy,H.Monenschein,H.H.Schiffer,C.Lutomski,C.V.Robinson, J.Liu,T.Hua,V.Katritch,V.Cherezov

Key ref:

M.Barekatain et al. Structural insights into the high basal activity and agonism of the orphan receptor gpr6 implicated in parkinson'S disease. Sci signal, . PubMed id: 39626010

Date:

26-Aug-23 Release date: 04-Dec-24

Protein chain

P46095  (GPR6_HUMAN) -  G-protein coupled receptor 6 from Homo sapiens

Seq: 362 a.a.

Struc: 264 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 237 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain C: E.C.3.6.5.- - ?????