PDBsum entry 8tf5

Membrane protein

PDB id: 8tf5

Contents

Protein chain

364 a.a.

Ligands

OLC ×5

P15 ×2

OLA ×12

CLR

Waters ×74

PDB id:

8tf5

Name:

Membrane protein

Title:

Crystal structure of orphan g protein-coupled receptor 6, pseudoapo form

Structure:

G-protein coupled receptor 6,soluble cytochrome b562 chimera,soluble cytochrome b562,g-protein coupled receptor 6. Chain: a. Synonym: cytochrome b-562. Engineered: yes. Mutation: yes

Source:

Homo sapiens, escherichia coli. Human. Organism_taxid: 9606, 562. Gene: gpr6, cybc. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.10Å R-factor: 0.186 R-free: 0.214

Authors:

M.Barekatain,L.Johansson,J.H.Lam,A.V.Sadybekov,G.W.Han,P.Popov, J.Russo,J.Bliesath,N.Brice,M.Beresford,L.Carlson,K.S.Saikatendu, H.Sun,S.Murphy,H.Monenschein,H.H.Schiffer,C.Lutomski,C.V.Robinson, Z.Liu,T.Hua,V.Katritch,V.Cherezov

Key ref:

M.Barekatain et al. Structural insights into the high basal activity and agonism of the orphan receptor gpr6 implicated in parkinson'S disease. Sci signal, . PubMed id: 39626010

Date:

07-Jul-23 Release date: 04-Dec-24

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 364 a.a.*

Protein chain

P46095  (GPR6_HUMAN) -  G-protein coupled receptor 6 from Homo sapiens

Seq: 362 a.a.

Struc: 364 a.a.*

* PDB and UniProt seqs differ at 126 residue positions (black crosses)