PDBsum entry 8rw0

Membrane protein

PDB id: 8rw0

Contents

Protein chain

386 a.a.

Ligands

JQ9

CLR ×3

OLA ×23

Metals

_NA

Waters ×119

PDB id:

8rw0

Name:

Membrane protein

Title:

Crystal structure of the adenosine a2a receptor in complex with istradefylline

Structure:

Adenosine receptor a2a,soluble cytochrome b562. Chain: a. Synonym: cytochrome b-562. Engineered: yes. Other_details: a2a-star2-bril562 construct (a2a with bril insertion), with a277s revert mutation.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: adora2a, adora2, cybc. Expressed in: trichoplusia ni. Expression_system_taxid: 7111

Resolution:

1.94Å R-factor: 0.194 R-free: 0.217

Authors:

H.Glover

Key ref:

H.Glover et al. (2024). Photoswitch dissociation from a g protein-Coupled rec resolved by time-Resolved serial crystallography.. Nat commun, 15, 10837. PubMed id: 39738009 DOI: 10.1038/S41467-024-55109-W

Date:

02-Feb-24 Release date: 08-Jan-25

Protein chain

P29274  (AA2AR_HUMAN) -  Adenosine receptor A2a from Homo sapiens

Seq: 412 a.a.

Struc: 386 a.a.*

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 386 a.a.*

* PDB and UniProt seqs differ at 116 residue positions (black crosses)