PDBsum entry 8kig

Membrane protein

PDB id: 8kig

Contents

Protein chain

258 a.a.

Ligands

ACE-NLE-ASP-HIS-4J2-ARG-TRP-LYS-NH2

Metals

_CA

PDB id:

8kig

Name:

Membrane protein

Title:

Cryo-em structure of mc3r in complex with shu9119

Structure:

Soluble cytochrome b562,melanocortin receptor 3,glga glycogen synthase,fusion protein. Chain: r. Synonym: cytochrome b-562,mc3-r,glycogen synthase. Engineered: yes. Shu9119. Chain: l. Engineered: yes

Source:

Escherichia coli, homo sapiens, pyrococcus abyssi ge5, synthetic construct. Human. Organism_taxid: 562, 9606, 272844, 32630. Gene: cybc, mc3r, pab2292. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Synthetic construct.

Authors:

Q.Chen,J.Fu

Key ref:

F.Jingpeng and h.hongli Structure basis of ligand selectivity and signal transduction in human melanocortin-3 receptor. To be published, .

Date:

23-Aug-23 Release date: 26-Feb-25

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 258 a.a.*

Protein chain

P41968  (MC3R_HUMAN) -  Melanocortin receptor 3 from Homo sapiens

Seq: 323 a.a.

Struc: 258 a.a.

Protein chain

Q9V2J8  (Q9V2J8_PYRAB) -  Glycogen synthase from Pyrococcus abyssi (strain GE5 / Orsay)

Seq: 437 a.a.

Struc: 258 a.a.*

* PDB and UniProt seqs differ at 357 residue positions (black crosses)