PDBsum entry 8k4o

Viral protein

PDB id: 8k4o

Contents

Protein chains

333 a.a.

63 a.a.

336 a.a.

229 a.a.

54 a.a.

PDB id:

8k4o

Name:

Viral protein

Title:

Cryo-em structure of kaposi's sarcoma-associated herpesvirus-g protein-coupled receptor (kshv-gpcr)in complex with cxc chemokine cxcl1

Structure:

G protein-coupled receptor. Chain: e. Engineered: yes. Growth-regulated alpha protein. Chain: f. Synonym: c-x-c motif chemokine 1,gro-alpha(1-73),melanoma growth stimulatory activity,mgsa,neutrophil-activating protein 3,nap-3. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Human gammaherpesvirus 8. Organism_taxid: 37296. Gene: orf74. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606. Gene: cxcl1, gro, gro1, groa, mgsa, scyb1.

Authors:

Y.Z.Liu,A.J.Liu

Key ref:

Y.Z.Liu and a.j.liu Cryo-Em structure of kaposi'S sarcoma herpesvirus gpc (kshv-Gpcr)in complex with cxcl1. To be published, . PubMed id: 39378089

Date:

20-Jul-23 Release date: 24-Jul-24

Protein chain

Q98146  (VGPCR_HHV8P) -  viral G-protein coupled receptor from Human herpesvirus 8 type P (isolate GK18)

Seq: 342 a.a.

Struc: 333 a.a.

Protein chain

P09341  (GROA_HUMAN) -  Growth-regulated alpha protein from Homo sapiens

Seq: 107 a.a.

Struc: 63 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 229 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Enzyme reactions

• Enzyme class: Chain C: E.C.3.6.5.- - ?????