PDBsum entry 8jzp

Signaling protein/immune system

PDB id: 8jzp

Contents

Protein chains

294 a.a.

208 a.a.

338 a.a.

71 a.a.

56 a.a.

232 a.a.

PDB id:

8jzp

Name:

Signaling protein/immune system

Title:

Structure of mouse c5a-human c5ar1-go complex

Structure:

C5a anaphylatoxin chemotactic receptor 1. Chain: a. Synonym: c5a anaphylatoxin chemotactic receptor,c5a-r,c5ar. Engineered: yes. Guanine nucleotide-binding protein g(o) subunit alpha. Chain: b. Engineered: yes. Mutation: yes. Other_details: this is a variant of guanine nucleotide-binding

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: c5ar1, c5ar, c5r1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnao1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Authors:

M.K.Yadav,R.Yadav,J.Maharana,P.Sarma,R.Banerjee,A.K.Shukla,C.Gati

Key ref:

M.K.Yadav et al. Structure of mouse c5a-Human c5ar1-Go complex. To be published, .

Date:

06-Jul-23 Release date: 15-Jan-25

Protein chain

P21730  (C5AR1_HUMAN) -  C5a anaphylatoxin chemotactic receptor 1 from Homo sapiens

Seq: 350 a.a.

Struc: 294 a.a.

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 208 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P06684  (CO5_MOUSE) -  Complement C5 from Mus musculus

Seq: 1680 a.a.

Struc: 71 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????