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PDBsum entry 8jru
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protein ligands Protein-protein interface(s) links
Membrane protein PDB id
8jru

 

 

 

 

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Contents
Protein chains
267 a.a.
346 a.a.
117 a.a.
107 a.a.
110 a.a.
Ligands
PIO
PDB id:
8jru
Name: Membrane protein
Title: Cryo-em structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state
Structure: Ha signal peptide,hpc4 purification tag,glucagon receptor, c-terminal tail of vasopressin v2 receptor. Chain: r. Synonym: gl-r,v2r,avpr v2,antidiuretic hormone receptor,renal-type arginine vasopressin receptor. Engineered: yes. Beta-arrestin 1 and single-chain fragment variable 30 (scfv30). Chain: a, h, l.
Source: Influenza a virus (strain a/victoria/3/1975 h3n2), homo sapiens. Human. Organism_taxid: 392809, 9606. Gene: ha, proc, gcgr, avpr2, adhr, dir, dir3, v2r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Bos taurus. Organism_taxid: 9913.
Authors: K.Chen,C.Zhang,S.Lin,Q.Zhao,B.Wu
Key ref: K.Chen et al. Tail engagement of arrestin at the glucagon receptor.. Nature, . PubMed id: 37558880
Date:
17-Jun-23     Release date:   16-Aug-23    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
P03435  (HEMA_I75A3) -  Hemagglutinin from Influenza A virus (strain A/Victoria/3/1975 H3N2)
Seq:
Struc: 		 
Seq:
Struc: 		567 a.a.
267 a.a.*
Protein chain
P04070  (PROC_HUMAN) -  Vitamin K-dependent protein C from Homo sapiens
Seq:
Struc: 		461 a.a.
267 a.a.*
Protein chain
P30518  (V2R_HUMAN) -  Vasopressin V2 receptor from Homo sapiens
Seq:
Struc: 		371 a.a.
267 a.a.*
Protein chain
P47871  (GLR_HUMAN) -  Glucagon receptor from Homo sapiens
Seq:
Struc: 		477 a.a.
267 a.a.*
Protein chain
P17870  (ARRB1_BOVIN) -  Beta-arrestin-1 from Bos taurus
Seq:
Struc: 		418 a.a.
346 a.a.*
Protein chain
P17870  (ARRB1_BOVIN) -  Beta-arrestin-1 from Bos taurus
Seq:
Struc: 		418 a.a.
117 a.a.*
Protein chain
P17870  (ARRB1_BOVIN) -  Beta-arrestin-1 from Bos taurus
Seq:
Struc: 		418 a.a.
107 a.a.*
Protein chain
No UniProt id for this chain
Struc: 110 a.a.
Key:    Secondary structure
* PDB and UniProt seqs differ at 938 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chain R: E.C.3.4.21.69  - activated protein C (thrombin-activated peptidase).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Degradation of blood coagulation factors Va and VIIIa.

 

 

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