PDBsum entry 8jis

Structural protein

PDB id: 8jis

Contents

Protein chains

238 a.a.

338 a.a.

29 a.a.

57 a.a.

126 a.a.

386 a.a.

PDB id:

8jis

Name:

Structural protein

Title:

Cryo-em structure of the glp-1r/gcgr dual agonist peptide15-bound human glp-1r-gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: gnb1.

Authors:

L.Yang,Q.T.Zhou,A.T.Dai,F.H.Zhao,R.L.Chang,T.L.Ying,B.L.Wu,D.H.Yang, M.W.Wang,Z.T.Cong

Key ref:

Y.Li et al. (2023). Structural analysis of the dual agonism at glp-1r and. Proc natl acad sci usa, 120, 96120. PubMed id: 37549266

Date:

27-May-23 Release date: 08-Nov-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 238 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 238 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

No UniProt id for this chain

Struc: 29 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 386 a.a.

* PDB and UniProt seqs differ at 194 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????