PDBsum entry 8jhb

Membrane protein

PDB id: 8jhb

Contents

Protein chains

239 a.a.

337 a.a.

57 a.a.

126 a.a.

334 a.a.

PDB id:

8jhb

Name:

Membrane protein

Title:

Fzd6 gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein,extra large alphas protein,xlalphas. Engineered: yes. Mutation: yes. Other_details: mingas. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gnb1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.

Authors:

F.Xu,Z.Zhang

Key ref:

Z.Zhang et al. (2024). A framework for frizzled-G protein coupling and impli to the pcp signaling pathways.. Cell discov, 10, 3. PubMed id: 38182578

Date:

23-May-23 Release date: 17-Jan-24

Protein chain

Q5JWF2  (GNAS1_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas from Homo sapiens

Seq: 1037 a.a.

Struc: 239 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

O60353  (FZD6_HUMAN) -  Frizzled-6 from Homo sapiens

Seq: 706 a.a.

Struc: 334 a.a.

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????