PDBsum entry 8j22

Membrane protein

PDB id: 8j22

Contents

Protein chains

340 a.a.

215 a.a.

285 a.a.

57 a.a.

235 a.a.

Ligands

9UJ

PDB id:

8j22

Name:

Membrane protein

Title:

Cryo-em structure of ffar2 complex bound with tug-1375

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: a. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: b. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnai1. Gene: ffar2, ffa2, gpcr43, gpr43. Gene: gng2.

Authors:

L.Tai,F.Li,X.Sun,W.Tang,J.Wang

Key ref:

F.Li et al. Molecular recognition and activation mechanism of short-Chain fatty acid receptors ffar2/3.. Cell res, . PubMed id: 38191689

Date:

14-Apr-23 Release date: 24-Jan-24

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 340 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 215 a.a.

Protein chain

O15552  (FFAR2_HUMAN) -  Free fatty acid receptor 2 from Homo sapiens

Seq: 330 a.a.

Struc: 285 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 235 a.a.

* PDB and UniProt seqs differ at 10 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????