PDBsum entry 8iyh

Signaling protein

PDB id: 8iyh

Contents

Protein chains

338 a.a.

206 a.a.

288 a.a.

56 a.a.

231 a.a.

Ligands

FI7

PDB id:

8iyh

Name:

Signaling protein

Title:

Structure of mk6892-gpr109a-g-protein complex

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: a. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(o) subunit alpha. Chain: b. Engineered: yes. Mutation: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gnao1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Authors:

M.K.Yadav,P.Sarma,M.Chami,R.Banerjee,A.K.Shukla

Key ref:

M.K.Yadav et al. Structure-Guided engineering of biased-Agonism in the niacin receptor via single amino acid substitution. Nat commun, . PubMed id: 38431681

Date:

04-Apr-23 Release date: 06-Mar-24

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 206 a.a.*

Protein chain

P08173  (ACM4_HUMAN) -  Muscarinic acetylcholine receptor M4 from Homo sapiens

Seq: 479 a.a.

Struc: 288 a.a.*

Protein chain

Q8TDS4  (HCAR2_HUMAN) -  Hydroxycarboxylic acid receptor 2 from Homo sapiens

Seq: 363 a.a.

Struc: 288 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

* PDB and UniProt seqs differ at 289 residue positions (black crosses)