PDBsum entry 8iy5

Peptide binding protein

PDB id: 8iy5

Contents

Protein chains

219 a.a.

336 a.a.

53 a.a.

232 a.a.

316 a.a.

21 a.a.

PDB id:

8iy5

Name:

Peptide binding protein

Title:

Etb-gi complex bound to endothelin-1

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus rattus. Organism_taxid: 10117. Bos taurus.

Authors:

F.K.Sano,H.Akasaka,W.Shihoya,O.Nureki

Key ref:

F.K.Sano et al. (2023). Cryo-Em structure of the endothelin-1-Etb-Gi complex.. Elife, 12, . PubMed id: 37096326

Date:

04-Apr-23 Release date: 16-Aug-23

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 219 a.a.

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P24530  (EDNRB_HUMAN) -  Endothelin receptor type B from Homo sapiens

Seq: 442 a.a.

Struc: 316 a.a.

Protein chain

P05305  (EDN1_HUMAN) -  Endothelin-1 from Homo sapiens

Seq: 212 a.a.

Struc: 21 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????