PDBsum entry 8ijb

Membrane protein

PDB id: 8ijb

Contents

Protein chains

294 a.a.

337 a.a.

216 a.a.

56 a.a.

233 a.a.

Ligands

OJX

PDB id:

8ijb

Name:

Membrane protein

Title:

Cryo-em structure of human hcar2-gi complex with acipimox

Structure:

Hydroxycarboxylic acid receptor 2. Chain: a. Synonym: g-protein coupled receptor 109a,g-protein coupled receptor hm74a,niacin receptor 1,nicotinic acid receptor. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hcar2, gpr109a, hca2, hm74a, niacr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gnai1. Gene: gng2.

Authors:

X.Pan,Y.Fang

Key ref:

X.Pan et al. (2023). Structural insights into ligand recognition and selec of the human hydroxycarboxylic acid receptor hcar2.. Cell discov, 9, 118. PubMed id: 38012147

Date:

27-Feb-23 Release date: 03-Jan-24

Protein chain

Q8TDS4  (HCAR2_HUMAN) -  Hydroxycarboxylic acid receptor 2 from Homo sapiens

Seq: 363 a.a.

Struc: 294 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 216 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)