PDBsum entry 8ibu

Signaling protein

PDB id: 8ibu

Contents

Protein chains

232 a.a.

338 a.a.

230 a.a.

54 a.a.

273 a.a.

Ligands

ERY

PDB id:

8ibu

Name:

Signaling protein

Title:

Cryo-em structure of the erythromycin-bound motilin receptor-gq protein complex

Structure:

Guanine nucleotide-binding protein g(q) subunit alpha. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Scfv16. Chain: e.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Escherichia coli, homo sapiens. Organism_taxid: 562, 9606.

Authors:

C.You,Y.Jiang,H.E.Xu,Y.Xu

Key ref:

C.You et al. (2023). Structural basis for motilin and erythromycin recogni motilin receptor.. Sci adv, 9, e9020. PubMed id: 36921049

Date:

10-Feb-23 Release date: 12-Apr-23

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

O43193  (MTLR_HUMAN) -  Motilin receptor from Homo sapiens

Seq: 412 a.a.

Struc: 273 a.a.

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 273 a.a.*

* PDB and UniProt seqs differ at 108 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains B, G, R: E.C.?