PDBsum entry 8i97

Signaling protein/immune system

PDB id: 8i97

Contents

Protein chains

276 a.a.

210 a.a.

338 a.a.

56 a.a.

233 a.a.

PDB id:

8i97

Name:

Signaling protein/immune system

Title:

Structure of apo-c3ar-go complex (glacios)

Structure:

C3a anaphylatoxin chemotactic receptor. Chain: c. Synonym: c3ar,c3a-r. Engineered: yes. Guanine nucleotide-binding protein g(o) subunit alpha. Chain: a. Fragment: unp residues 4-57,unp residues 182-354. Engineered: yes. Mutation: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: c3ar1, az3b, c3r1, hnfag09. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnao1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Authors:

M.K.Yadav,R.Yadav,J.Maharana,P.Sarma,R.Banerjee,A.K.Shukla,C.Gati

Key ref:

M.K.Yadav et al. Molecular basis of anaphylatoxin binding, Activation, Signaling bias at complement receptors. Cell(cambridge,Mass ), . PubMed id: 37852260

Date:

06-Feb-23 Release date: 18-Oct-23

Protein chain

Q16581  (C3AR_HUMAN) -  C3a anaphylatoxin chemotactic receptor from Homo sapiens

Seq: 482 a.a.

Struc: 276 a.a.

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 210 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????