PDBsum entry 8hoc

Membrane protein

PDB id: 8hoc

Contents

Protein chains

225 a.a.

338 a.a.

57 a.a.

276 a.a.

231 a.a.

Ligands

ITF

PDB id:

8hoc

Name:

Membrane protein

Title:

Cryo-em structure of ligand histamine-bound histamine h4 receptor gi complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: cybc, hrh4, gpcr105.

Authors:

W.Q.Tang,X.Y.Sun,F.H.Li,J.Y.Wang

Key ref:

X.Y.Sun et al. Structure insights into histamine h4 receptor activat an endogenous ligand histamine and agonist imetit. To be published, .

Date:

09-Dec-22 Release date: 20-Dec-23

Protein chain

A0A811MS43  (A0A811MS43_9POAL) -  Protein kinase domain-containing protein from Miscanthus lutarioriparius

Seq: 435 a.a.

Struc: 225 a.a.*

Protein chain

No UniProt id for this chain

Struc: 338 a.a.

Protein chain

No UniProt id for this chain

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 276 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

* PDB and UniProt seqs differ at 186 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????