PDBsum entry 8hk5

Membrane protein

PDB id: 8hk5

Contents

Protein chains

293 a.a.

74 a.a.

224 a.a.

328 a.a.

48 a.a.

Ligands

PLM ×2

PDB id:

8hk5

Name:

Membrane protein

Title:

C5ar1-gi-c5a protein complex

Structure:

C5a anaphylatoxin chemotactic receptor 1. Chain: a. Engineered: yes. Complement c5. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: c. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: c5ar1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: c5. Gene: gnai1. Rattus norvegicus.

Authors:

Y.Wang,W.Liu,Y.Xu,Y.Zhuang,H.E.Xu

Key ref:

Y.Wang et al. Illumination of the complement receptors c3ar and c5a signaling by anaphylatoxins. To be published, . PubMed id: 37169960

Date:

24-Nov-22 Release date: 10-May-23

Protein chain

P21730  (C5AR1_HUMAN) -  C5a anaphylatoxin chemotactic receptor 1 from Homo sapiens

Seq: 350 a.a.

Struc: 293 a.a.

Protein chain

P01031  (CO5_HUMAN) -  Complement C5 from Homo sapiens

Seq: 1676 a.a.

Struc: 74 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 224 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 328 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 48 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain C: E.C.3.6.5.- - ?????