PDBsum entry 8h4i

Membrane protein/immune system

PDB id: 8h4i

Contents

Protein chains

231 a.a.

338 a.a.

56 a.a.

127 a.a.

283 a.a.

Ligands

HXA

PDB id:

8h4i

Name:

Membrane protein/immune system

Title:

Dha-bound ffar4 in complex with gs

Structure:

Engineered mini galpha-s subunit. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Lama glama. Llama.

Authors:

Y.He,H.Yin

Key ref:

H.Yin et al. Structural basis of omega-3 fatty acid receptor ffar4 activation and g protein coupling selectivity.. Cell res, . PubMed id: 37286793

Date:

10-Oct-22 Release date: 21-Jun-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 231 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 231 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

Q5NUL3  (FFAR4_HUMAN) -  Free fatty acid receptor 4 from Homo sapiens

Seq: 361 a.a.

Struc: 283 a.a.

* PDB and UniProt seqs differ at 199 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????