PDBsum entry 8gti

Membrane protein

PDB id: 8gti

Contents

Protein chains

263 a.a.

160 a.a.

Ligands

OLA ×5

0JS

PDB id:

8gti

Name:

Membrane protein

Title:

Corticotropin-releasing hormone receptor 1(crf1r) bound with bmk-c205 by xfel

Structure:

Isoform crf-r2 of corticotropin-releasing factor receptor 1. Chain: a. Synonym: crf-r-1,crf-r1,crfr-1,corticotropin-releasing hormone receptor 1,crh-r-1,crh-r1. Engineered: yes. Mutation: yes. Endolysin. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: crhr1, crfr, crfr1, crhr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Enterobacteria phage t6. Organism_taxid: 10666. Gene: e, ect6_00117.

Resolution:

2.20Å R-factor: 0.209 R-free: 0.237

Authors:

H.S.Cho,H.Kim

Key ref:

H.Kim et al. Structure-Based drug discovery of a corticotropin-Rel hormone receptor 1 antagonist using an X-Ray free-Ele laser. Exp mol med, . PubMed id: 37653040

Date:

08-Sep-22 Release date: 13-Sep-23

Protein chain

P34998  (CRFR1_HUMAN) -  Corticotropin-releasing factor receptor 1 from Homo sapiens

Seq: 415 a.a.

Struc: 263 a.a.*

Protein chain

A0A346FJK3  (A0A346FJK3_BPT6) -  Endolysin from Enterobacteria phage T6

Seq: 164 a.a.

Struc: 160 a.a.*

* PDB and UniProt seqs differ at 14 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.2.1.17 - lysozyme.
• Reaction: Hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls.