PDBsum entry 8g59

Membrane protein

PDB id: 8g59

Contents

Protein chains

335 a.a.

53 a.a.

230 a.a.

219 a.a.

281 a.a.

Ligands

YN9

PDB id:

8g59

Name:

Membrane protein

Title:

Cryo-em structure of the tug891 bound gpr120-giq complex

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2. Chain: y. Synonym: g gamma-i.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gng2. Variant: g203a a326s. Gene: gnai1, gnaq, gaq.

Authors:

C.Mao,P.Xiao,X.Tao,J.Qin,Q.He,C.Zhang,X.Yu,Y.Zhang,J.Sun

Key ref:

C.Mao et al. Unsaturated bond recognition leads to biased signal i fatty acid receptor. Science, . PubMed id: 36862765

Date:

12-Feb-23 Release date: 08-Mar-23

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 335 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P50148  (GNAQ_HUMAN) -  Guanine nucleotide-binding protein G(q) subunit alpha from Homo sapiens

Seq: 359 a.a.

Struc: 219 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 219 a.a.*

Protein chain

Q5NUL3  (FFAR4_HUMAN) -  Free fatty acid receptor 4 from Homo sapiens

Seq: 361 a.a.

Struc: 281 a.a.

* PDB and UniProt seqs differ at 124 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????