PDBsum entry 8f2b

Signaling protein/immune system

PDB id: 8f2b

Contents

Protein chains

228 a.a.

339 a.a.

55 a.a.

128 a.a.

117 a.a.

38 a.a.

369 a.a.

Ligands

D6M

NAG ×3

PLM ×8

P42

Y01 ×2

Waters ×31

PDB id:

8f2b

Name:

Signaling protein/immune system

Title:

Amylin 3 receptor in complex with gs and pramlintide analogue peptide san45

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

J.Cao,P.M.Sexton,D.L.Wootten,M.J.Belousoff

Key ref:

J.Cao et al. Structure-Based insight into development of selective non-Selective amylin and calcitonin receptor agonists. Nat chem biol, . PubMed id: 37537379

Date:

07-Nov-22 Release date: 02-Aug-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 228 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

O60896  (RAMP3_HUMAN) -  Receptor activity-modifying protein 3 from Homo sapiens

Seq: 148 a.a.

Struc: 117 a.a.

Protein chain

P10997  (IAPP_HUMAN) -  Islet amyloid polypeptide from Homo sapiens

Seq: 89 a.a.

Struc: 38 a.a.*

Protein chain

P30988  (CALCR_HUMAN) -  Calcitonin receptor from Homo sapiens

Seq: 474 a.a.

Struc: 369 a.a.

* PDB and UniProt seqs differ at 13 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????