PDBsum entry 8efq

Signaling protein

PDB id: 8efq

Contents

Protein chains

217 a.a.

336 a.a.

53 a.a.

283 a.a.

Ligands

TYR-DAL-GLY-MEA

ETA

PDB id:

8efq

Name:

Signaling protein

Title:

Damgo-bound mu-opioid receptor-gi complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Rat. Organism_taxid: 10116.

Authors:

Y.Zhuang,Y.Wang,S.Guo,X.E.Zhou,Q.Rao,X.He,B.He,J.Liu,Q.Zhou,X.Wang, W.Liu,X.Jiang,D.Yang,X.Chen,Y.Jiang,H.Jiang,J.Shen,K.Melcher,M.Wang, X.Xie,H.E.Xu

Key ref:

Y.Zhuang et al. Molecular recognition of morphine and fentanyl by the mu-Opioid receptor. Cell(cambridge,Mass ), . PubMed id: 36368306

Date:

08-Sep-22 Release date: 09-Nov-22

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

P35372  (OPRM_HUMAN) -  Mu-type opioid receptor from Homo sapiens

Seq: 400 a.a.

Struc: 283 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????