PDBsum entry 8dwh

Signaling protein

PDB id: 8dwh

Contents

Protein chains

221 a.a.

338 a.a.

51 a.a.

248 a.a.

Ligands

U2U

PDB id:

8dwh

Name:

Signaling protein

Title:

Cryoem structure of gq-coupled mrgprx1 with ligand compound-16

Structure:

Gs-mini-gq chimera. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: c. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: mrgprx1, mrgx1, snsr3, snsr4. Expression_system_taxid: 7108

Authors:

Y.Liu,C.Cao,J.F.Fay,B.L.Roth

Key ref:

Y.Liu et al. (2023). Ligand recognition and allosteric modulation of the h mrgprx1 receptor.. Nat chem biol, 19, 416. PubMed id: 36302898

Date:

01-Aug-22 Release date: 02-Nov-22

Protein chain

No UniProt id for this chain

Struc: 221 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 51 a.a.

Protein chain

Q96LB2  (MRGX1_HUMAN) -  Mas-related G-protein coupled receptor member X1 from Homo sapiens

Seq: 322 a.a.

Struc: 248 a.a.