PDBsum entry 8cu7

Membrane protein

PDB id: 8cu7

Contents

Protein chain

396 a.a.

Ligands

PEG ×4

LJX

OLC ×7

OLA ×23

CLR ×3

ETF

Metals

_NA

Waters ×177

PDB id:

8cu7

Name:

Membrane protein

Title:

Crystal structure of a2aar-star2-bril in complex with a novel a2a antagonist, lj-4517

Structure:

Adenosine receptor a2a,soluble cytochrome b562. Chain: a. Synonym: cytochrome b-562. Engineered: yes. Mutation: yes

Source:

Homo sapiens, escherichia coli. Human. Organism_taxid: 9606, 562. Gene: adora2a, adora2, cybc. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.05Å R-factor: 0.179 R-free: 0.211

Authors:

A.Shiriaeva,D.-J.Park,G.Kim,Y.Lee,X.Hou,D.B.Jarhad,G.Kim,J.Yu, Y.E.Hyun,W.Kim,Z.-G.Gao,K.A.Jacobson,G.W.Han,R.C.Stevens,L.S.Jeong, S.Choi,V.Cherezov

Key ref:

A.Shiriaeva et al. Gpcr agonist-To-Antagonist conversion: enabling the d of nucleoside functional switches for the a 2a adenos receptor.. J med chem, . PubMed id: 35977382

Date:

16-May-22 Release date: 31-Aug-22

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 396 a.a.*

Protein chain

P29274  (AA2AR_HUMAN) -  Adenosine receptor A2a from Homo sapiens

Seq: 412 a.a.

Struc: 396 a.a.*

* PDB and UniProt seqs differ at 120 residue positions (black crosses)