PDBsum entry 7xov

Neuropeptide

PDB id: 7xov

Contents

Protein chains

227 a.a.

338 a.a.

57 a.a.

126 a.a.

288 a.a.

Ligands

IA1

Waters ×1

PDB id:

7xov

Name:

Neuropeptide

Title:

Structural insights into human brain gut peptide cholecystokinin receptors

Structure:

Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Synthetic: yes.

Authors:

Y.Ding,H.Zhang,Y.Liao,L.Chen,S.Ji

Key ref:

Y.Ding et al. (2022). Structural insights into human brain-Gut peptide cholecystokinin receptors.. Cell discov, 8, 55. PubMed id: 35672283

Date:

01-May-22 Release date: 20-Jul-22

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 227 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P32238  (CCKAR_HUMAN) -  Cholecystokinin receptor type A from Homo sapiens

Seq: 428 a.a.

Struc: 288 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????