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UniProt functional annotation for P48645 | ||
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| UniProt code: P48645. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
[Neuromedin-U-25]: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. {ECO:0000250|UniProtKB:P12760}. |
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| Function: | |
[Neuromedin precursor-related peptide 33]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. {ECO:0000250|UniProtKB:P12760}. |
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| Function: | |
[Neuromedin precursor-related peptide 36]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. {ECO:0000250|UniProtKB:P12760}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed throughout the enteric nervous system with highest levels being found in the jejunum. |
| Similarity: | |
Belongs to the NmU family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.