UniProt functional annotation for Q80TS3



	UniProt functional annotation for Q80TS3

UniProt code: Q80TS3.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25728924, PubMed:26235031). Plays a role in the development of glutamatergic synapses in the cortex (PubMed:22405201, PubMed:24739570). Important in determining the connectivity rates between the principal neurons in the cortex (PubMed:24739570). {ECO:0000269|PubMed:22405201, ECO:0000269|PubMed:24739570, ECO:0000269|PubMed:25728924, ECO:0000269|PubMed:26235031}.

Subunit: Interacts (via olfactomedin-like domain) with FLRT3 (via extracellular domain); the interaction is direct(PubMed:22405201, PubMed:24739570, PubMed:26235031). Identified in a complex with FLRT3 and UNC5B; does not interact with UNC5B by itself. Identified in a complex with FLRT3 and UNC5D; does not interact with UNC5D by itself (By similarity). Interacts (via olfactomedin-like domain) with FLRT1 (via extracellular domain) (PubMed:22405201). Interacts (via olfactomedin-like domain) with FLRT2 (via extracellular domain) (PubMed:22405201, PubMed:25728924). Interacts (via extracellular domain) with TENM1 (PubMed:24739570). Interacts (via extracellular domain) with TENM3 (PubMed:22405201). {ECO:0000250|UniProtKB:Q9HAR2, ECO:0000269|PubMed:22405201, ECO:0000269|PubMed:24739570, ECO:0000269|PubMed:25728924, ECO:0000269|PubMed:26235031}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:22405201, ECO:0000269|PubMed:24739570}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:22405201}. Cell junction {ECO:0000269|PubMed:22405201}.

Domain: The Olfactomedin-like domain is required for the synapse- promoting function and the interaction with FLRT3. The Olfactomedin- like and the SUEL-type lectin domains are required for the interaction with TENM1. {ECO:0000269|PubMed:24739570}.

Ptm: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. {ECO:0000250}.

Ptm: O-glycosylated (major) and N-glycosylated. {ECO:0000269|PubMed:24739570}.

Disruption phenotype: Mutant mice are viable and present no obvious physical phenotype. Compared to wild-type, mutants are hyperactive, and their dorsal striatum contains higher levels of the neurotransmitters dopamine and serotonin. Cocaine treatment causes a higher increase in locomotor activity than in wild-type. {ECO:0000269|PubMed:22575564}.

Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25728924, PubMed:26235031). Plays a role in the development of glutamatergic synapses in the cortex (PubMed:22405201, PubMed:24739570). Important in determining the connectivity rates between the principal neurons in the cortex (PubMed:24739570). {ECO:0000269\|PubMed:22405201, ECO:0000269\|PubMed:24739570, ECO:0000269\|PubMed:25728924, ECO:0000269\|PubMed:26235031}.


Subunit:		Interacts (via olfactomedin-like domain) with FLRT3 (via extracellular domain); the interaction is direct(PubMed:22405201, PubMed:24739570, PubMed:26235031). Identified in a complex with FLRT3 and UNC5B; does not interact with UNC5B by itself. Identified in a complex with FLRT3 and UNC5D; does not interact with UNC5D by itself (By similarity). Interacts (via olfactomedin-like domain) with FLRT1 (via extracellular domain) (PubMed:22405201). Interacts (via olfactomedin-like domain) with FLRT2 (via extracellular domain) (PubMed:22405201, PubMed:25728924). Interacts (via extracellular domain) with TENM1 (PubMed:24739570). Interacts (via extracellular domain) with TENM3 (PubMed:22405201). {ECO:0000250\|UniProtKB:Q9HAR2, ECO:0000269\|PubMed:22405201, ECO:0000269\|PubMed:24739570, ECO:0000269\|PubMed:25728924, ECO:0000269\|PubMed:26235031}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:22405201, ECO:0000269\|PubMed:24739570}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269\|PubMed:22405201}. Cell junction {ECO:0000269\|PubMed:22405201}.
Domain:		The Olfactomedin-like domain is required for the synapse- promoting function and the interaction with FLRT3. The Olfactomedin- like and the SUEL-type lectin domains are required for the interaction with TENM1. {ECO:0000269\|PubMed:24739570}.
Ptm:		Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. {ECO:0000250}.
Ptm:		O-glycosylated (major) and N-glycosylated. {ECO:0000269\|PubMed:24739570}.
Disruption phenotype:		Mutant mice are viable and present no obvious physical phenotype. Compared to wild-type, mutants are hyperactive, and their dorsal striatum contains higher levels of the neurotransmitters dopamine and serotonin. Cocaine treatment causes a higher increase in locomotor activity than in wild-type. {ECO:0000269\|PubMed:22575564}.
Similarity:		Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. {ECO:0000305}.