PDBsum entry 7wuq

Membrane protein

PDB id: 7wuq

Contents

Protein chains

215 a.a.

334 a.a.

55 a.a.

127 a.a.

278 a.a.

PDB id:

7wuq

Name:

Membrane protein

Title:

Tethered peptide activation mechanism of adhesion gpcrs adgrg2 and adgrg4

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

Q.T.He,S.C.Guo,P.Xiao,J.P.Sun,X.Yu,L.Gou,L.L.Kong,L.Zhang

Key ref:

P.Xiao et al. Tethered peptide activation mechanism of the adhesion adgrg2 and adgrg4.. Nature, . PubMed id: 35418677

Date:

09-Feb-22 Release date: 27-Apr-22

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 215 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 334 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

Q8CJ12  (AGRG2_MOUSE) -  Adhesion G-protein coupled receptor G2 from Mus musculus

Seq: 1009 a.a.

Struc: 278 a.a.

* PDB and UniProt seqs differ at 41 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????