PDBsum entry 7w0c

RNA binding protein

PDB id: 7w0c

Contents

Protein chains

1476 a.a.

16 a.a.

DNA/RNA

Ligands

ADP

Metals

_MG

PDB id:

7w0c

Name:

RNA binding protein

Title:

Dicer2-loqs-pd-dsrna complex at early-translocation state

Structure:

Dicer-2, isoform a. Chain: a. Synonym: fi15132p1. Ec: 3.1.21.1,3.1.26.-,3.1.26.3,3.6.1.3. Engineered: yes. Loquacious, isoform d. Chain: b. Engineered: yes. RNA (35-mer).

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: dcr-2, cg6493, dcr, dcr, dcr-2, dcr-2, dcr-2-ra, dcr2, dcr2, dcr2, ddcr2, dic2, dicer, dicer, dicer, dicer-2, dicer-2, dicer2, dicer2, dmdcr-2, dmel\cg6493, cg6493, dmel_cg6493. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: loqs, cg6866, dmel\cg6866, drax, loq, loqs, loqs, loqs-pd,

Authors:

S.Su,J.Wang,H.W.Wang,J.Ma

Key ref:

S.Su et al. Structural insights into dsrna processing by drosophi dicer-2/loqs-Pd.. Nature, . PubMed id: 35768513

Date:

18-Nov-21 Release date: 27-Apr-22

Protein chain

A1ZAW0  (A1ZAW0_DROME) -  Endoribonuclease Dcr-2 from Drosophila melanogaster

Seq: 1722 a.a.

Struc: 1476 a.a.*

Protein chain

Q9VJY9  (Q9VJY9_DROME) -  Protein Loquacious from Drosophila melanogaster

Seq: 465 a.a.

Struc: 16 a.a.*

* PDB and UniProt seqs differ at 16 residue positions (black crosses)

DNA/RNA chains

G-A-G-A-C-U-U-G-G-G-C-A-A-U-G-U-G-A-C-U-G-C-U-G-A-U-C-A-G-C-A-G-U-C-A 35 bases

U-G-A-C-U-G-C-U-G-A-U-C-A-G-C-A-G-U-C-A-C-A-U-U-G-C-C-C-A-A-G-U-C-U-C-U-U 37 bases

Enzyme reactions

• Enzyme class: Chain A: E.C.3.1.26.3 - ribonuclease Iii.
• Reaction: Endonucleolytic cleavage to 5'-phosphomonoester.