UniProt functional annotation for P03521



	UniProt functional annotation for P03521

UniProt code: P03521.

Organism: Vesicular stomatitis Indiana virus (strain San Juan) (VSIV).

Taxonomy: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Rhabdoviridae; Vesiculovirus.

Function: Encapsidates the genome in a ratio of one N per nine ribonucleotides, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Nucleocapsid assembly is concommitant with replication, therefore viral replication depends on the intracellular concentration of free N, termed N(0). All replicative products are resistant to nucleases. {ECO:0000269|PubMed:22875970, ECO:0000269|PubMed:2986844}.

Subunit: Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA (PubMed:11000221). N in nucleocapsid binds the P protein and thereby positions the polymerase on the template (PubMed:3016338). Interaction of N(0) with the P protein prevents the uncontrolled aggregation of N(0) (PubMed:21207454). {ECO:0000269|PubMed:11000221, ECO:0000269|PubMed:21207454, ECO:0000269|PubMed:3016338}.

Subcellular location: Virion {ECO:0000269|PubMed:1850035}. Host cytoplasm. Note=The nucleocapsid is synthesized in the cytoplasm, and is subsequently transported via microtubules to the cell periphery.

Similarity: Belongs to the vesiculovirus nucleocapsid protein family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Vesicular stomatitis Indiana virus (strain San Juan) (VSIV).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Rhabdoviridae; Vesiculovirus.



Function:		Encapsidates the genome in a ratio of one N per nine ribonucleotides, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Nucleocapsid assembly is concommitant with replication, therefore viral replication depends on the intracellular concentration of free N, termed N(0). All replicative products are resistant to nucleases. {ECO:0000269\|PubMed:22875970, ECO:0000269\|PubMed:2986844}.


Subunit:		Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA (PubMed:11000221). N in nucleocapsid binds the P protein and thereby positions the polymerase on the template (PubMed:3016338). Interaction of N(0) with the P protein prevents the uncontrolled aggregation of N(0) (PubMed:21207454). {ECO:0000269\|PubMed:11000221, ECO:0000269\|PubMed:21207454, ECO:0000269\|PubMed:3016338}.
Subcellular location:		Virion {ECO:0000269\|PubMed:1850035}. Host cytoplasm. Note=The nucleocapsid is synthesized in the cytoplasm, and is subsequently transported via microtubules to the cell periphery.
Similarity:		Belongs to the vesiculovirus nucleocapsid protein family. {ECO:0000305}.