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UniProt functional annotation for P61765 | ||
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| UniProt code: P61765. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (PubMed:21689256). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000269|PubMed:21689256}. |
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| Subunit: | |
Interacts with SYTL4 (PubMed:12058058). Interacts with STX1A (PubMed:10746715). Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation (By similarity). Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (PubMed:21689256). Interacts with CABP5 (By similarity). {ECO:0000250|UniProtKB:P61763, ECO:0000250|UniProtKB:P61764, ECO:0000269|PubMed:10746715, ECO:0000269|PubMed:12058058, ECO:0000269|PubMed:21689256}. |
| Subcellular location: | |
Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61764}. Membrane; Peripheral membrane protein. |
| Tissue specificity: | |
Brain and spinal cord. Highly enriched in axons. |
| Developmental stage: | |
Faint levels are detectable at embryonic day 14, with levels rising at later embryonic ages and peaking at postnatal day 7. |
| Similarity: | |
Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.