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UniProt functional annotation for Q9IPJ8 | ||
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| UniProt code: Q9IPJ8. |
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| Organism: | |
Rabies virus (strain Nishigahara RCEH) (RABV). |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Rhabdoviridae; Lyssavirus. |
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| Function: | |
Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity). {ECO:0000250}. |
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| Subunit: | |
[Phosphoprotein]: Homotrimer when phosphorylated. This trimer is stabilized by binding to the L protein. Binds soluble protein N, and ribonucleocapsid. Interacts with host DYNLL1 and DYNLL2; this interaction may play a role in intracellular microtubule-dependent virus transport of incoming virus. Interacts with host STAT1, STAT2 and PML. {ECO:0000250}. |
| Subunit: | |
[Isoform P3]: Binds host PML. {ECO:0000250}. |
| Subcellular location: | |
[Phosphoprotein]: Virion. Host cytoplasm {ECO:0000250}. |
| Subcellular location: | |
[Isoform P2]: Host cytoplasm {ECO:0000250}. |
| Subcellular location: | |
[Isoform P3]: Host nucleus {ECO:0000250}. |
| Subcellular location: | |
[Isoform P4]: Host nucleus {ECO:0000250}. |
| Subcellular location: | |
[Isoform P5]: Host nucleus {ECO:0000250}. |
| Ptm: | |
Phosphorylated by host PKC and by an unknown kinase. {ECO:0000250}. |
| Similarity: | |
Belongs to the lyssavirus protein P family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.