UniProt functional annotation for Q8U093

UniProt code: Q8U093.

Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
Taxonomy: Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.
 
Function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. {ECO:0000250}.
 
Catalytic activity: Reaction=(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan; Xref=Rhea:RHEA:10532, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:57912, ChEBI:CHEBI:58866, ChEBI:CHEBI:59776; EC=4.2.1.20;
Cofactor: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Pathway: Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 5/5.
Subunit: Tetramer of two alpha and two beta chains. {ECO:0000250}.
Similarity: Belongs to the TrpB family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.