PDBsum entry 7rh2

Transcription

PDB id: 7rh2

Contents

Protein chains

108 a.a.

DNA/RNA

Waters ×13

PDB id:

7rh2

Name:

Transcription

Title:

Irf4 transcription factor mutant -k59r

Structure:

Icsat transcription factor. Chain: a, b, g, h. Engineered: yes. Mutation: yes. DNA (5'- d( Cp Ap Ap Cp Tp Gp Ap Ap Ap Cp Cp Gp Ap Gp Ap Ap Ap Gp C)-3'). Chain: c, d. Engineered: yes. DNA (5'-

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.47Å R-factor: 0.205 R-free: 0.241

Authors:

S.J.Williams,S.Sundararaj,M.G.Casarotto

Key ref:

S.Sundararaj et al. (2022). The molecular basis for the development of adult t-Ce leukemia/lymphoma in patients with an irf4 k59r mutat. Protein sci, 31, 787. PubMed id: 34913532

Date:

16-Jul-21 Release date: 25-May-22

Protein chains

Q15306  (IRF4_HUMAN) -  Interferon regulatory factor 4 from Homo sapiens

Seq: 451 a.a.

Struc: 108 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

DNA/RNA chains

C-A-A-C-T-G-A-A-A-C-C-G-A-G-A-A-A-G-C 19 bases

C-A-A-C-T-G-A-A-A-C-C-G-A-G-A-A-A-G-C 19 bases

G-C-T-T-T-C-T-C-G-G-T-T-T-C-A-G-T-T-G 19 bases

C-T-T-T-C-T-C-G-G-T-T-T-C-A-G-T-T-G 18 bases