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UniProt functional annotation for Q8WUA2 | ||
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| UniProt code: Q8WUA2. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; |
| Subcellular location: | |
Nucleus {ECO:0000305}. |
| Tissue specificity: | |
Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult tissues. {ECO:0000269|PubMed:11978968}. |
| Similarity: | |
Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.