PDBsum entry 7qna

Membrane protein

PDB id: 7qna

Contents

Protein chains

333 a.a.

327 a.a.

328 a.a.

121 a.a.

Ligands

NAG-NAG-BMA-MAN-MAN ×4

NAG-NAG ×3

NAG ×2

ABU

PDB id:

7qna

Name:

Membrane protein

Title:

Cryo-em structure of human full-length alpha4beta3gamma2 gaba(a)r in complex with gaba and nanobody nb25

Structure:

Gamma-aminobutyric acid receptor subunit alpha-4. Chain: a. Synonym: gaba(a) receptor subunit alpha-4. Engineered: yes. Gamma-aminobutyric acid receptor subunit beta-3. Chain: b, d, e. Synonym: gaba(a) receptor subunit beta-3. Engineered: yes. Gamma-aminobutyric acid receptor subunit gamma-2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gabra4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s tetr. Gene: gabrb3. Gene: gabrg2.

Authors:

A.Sente,R.Desai,K.Naydenova,T.Malinauskas,Y.Jounaidi,J.Miehling, X.Zhou,S.Masiulis,S.W.Hardwick,D.Y.Chirgadze,K.W.Miller,A.R.Aricescu

Key ref:

A.Sente et al. Differential assembly diversifies gaba a receptor str and signalling.. Nature, . PubMed id: 35355020

Date:

20-Dec-21 Release date: 13-Apr-22

Protein chain

P48169  (GBRA4_HUMAN) -  Gamma-aminobutyric acid receptor subunit alpha-4 from Homo sapiens

Seq: 554 a.a.

Struc: 333 a.a.*

Protein chains

P28472  (GBRB3_HUMAN) -  Gamma-aminobutyric acid receptor subunit beta-3 from Homo sapiens

Seq: 473 a.a.

Struc: 327 a.a.*

Protein chain

P18507  (GBRG2_HUMAN) -  Gamma-aminobutyric acid receptor subunit gamma-2 from Homo sapiens

Seq: 475 a.a.

Struc: 328 a.a.

Protein chain

No UniProt id for this chain

Struc: 121 a.a.

* PDB and UniProt seqs differ at 54 residue positions (black crosses)