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UniProt functional annotation for Q8TB45 | ||
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| UniProt code: Q8TB45. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes. {ECO:0000269|PubMed:19446321}. |
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| Subunit: | |
Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2 (PubMed:19446321). Interacts (via PDZ domain) with MINAR1 (via N-terminus) (PubMed:30080879). Interacts with SIK3 (PubMed:30232230). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:30080879, ECO:0000269|PubMed:30232230}. |
| Induction: | |
Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level). {ECO:0000269|PubMed:19446321}. |
| Ptm: | |
Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2. {ECO:0000269|PubMed:19446321}. |
| Ptm: | |
Ubiquitinated; ubiquitination leads to proteasomal degradation. {ECO:0000269|PubMed:30080879}. |
| Sequence caution: | |
Sequence=BAB14723.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.