UniProt functional annotation for P14210



	UniProt functional annotation for P14210

UniProt code: P14210.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. {ECO:0000269|PubMed:15167892, ECO:0000269|PubMed:20624990}.

Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity. {ECO:0000269|PubMed:15167892, ECO:0000269|PubMed:22242148}.

Disease: Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:19576567}. Note=The disease is caused by variants affecting the gene represented in this entry.

Miscellaneous: [Isoform 4]: Acts as a competitive antagonist in MET- signaling. {ECO:0000305}.

Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. {ECO:0000269\|PubMed:15167892, ECO:0000269\|PubMed:20624990}.


Subunit:		Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity. {ECO:0000269\|PubMed:15167892, ECO:0000269\|PubMed:22242148}.
Disease:		Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269\|PubMed:19576567}. Note=The disease is caused by variants affecting the gene represented in this entry.
Miscellaneous:		[Isoform 4]: Acts as a competitive antagonist in MET- signaling. {ECO:0000305}.
Similarity:		Belongs to the peptidase S1 family. Plasminogen subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00274}.