UniProt functional annotation for Q8VHW5



	UniProt functional annotation for Q8VHW5

UniProt code: Q8VHW5.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000250|UniProtKB:Q8VHW2, ECO:0000269|PubMed:17880894, ECO:0000269|PubMed:19234459}.

Subunit: Interacts with CACNA1C. Identified in a complex with the L- type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8VHW2}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8VHW2}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic density membrane {ECO:0000250|UniProtKB:Q8VHW2}.

Ptm: Palmitoylated (PubMed:23687301). Probably palmitoylated by ZDHHC3 and ZDHHC7 (PubMed:23687301). {ECO:0000269|PubMed:23687301}.

Similarity: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000250\|UniProtKB:Q8VHW2, ECO:0000269\|PubMed:17880894, ECO:0000269\|PubMed:19234459}.


Subunit:		Interacts with CACNA1C. Identified in a complex with the L- type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or CACNB2 (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q8VHW2}.
Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:Q8VHW2}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic density membrane {ECO:0000250\|UniProtKB:Q8VHW2}.
Ptm:		Palmitoylated (PubMed:23687301). Probably palmitoylated by ZDHHC3 and ZDHHC7 (PubMed:23687301). {ECO:0000269\|PubMed:23687301}.
Similarity:		Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. {ECO:0000305}.