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UniProt functional annotation for Q8K424 | ||
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| UniProt code: Q8K424. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity). {ECO:0000250, ECO:0000269|PubMed:12016205}. |
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| Subunit: | |
May form a heteromeric channel with TRPV1. Interacts with TRPV1 (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue specificity: | |
Expressed in keratinocytes and hair follicles. {ECO:0000269|PubMed:12016205}. |
| Similarity: | |
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.