UniProt functional annotation for Q4VCS5



	UniProt functional annotation for Q4VCS5

UniProt code: Q4VCS5.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097}.

Subunit: Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin. {ECO:0000269|PubMed:16043488, ECO:0000269|PubMed:16678097}.

Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:16043488}. Note=Localized on the cell surface. May act as a transmembrane protein.

Tissue specificity: Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta. {ECO:0000269|PubMed:11257124}.

Domain: The coiled coil domain interacts directly with the BAR domain of ARHGAP17. {ECO:0000269|PubMed:16678097}.

Domain: The angiostatin binding domain (871-1005) allows the binding to angiostatin. {ECO:0000269|PubMed:16678097}.

Ptm: Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation. {ECO:0000269|PubMed:22385262}.

Miscellaneous: 'Motus' means 'motility' in Latin.

Similarity: Belongs to the angiomotin family. {ECO:0000305}.

Sequence caution: Sequence=AAH94712.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. {ECO:0000269\|PubMed:11257124, ECO:0000269\|PubMed:16678097}.


Subunit:		Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin. {ECO:0000269\|PubMed:16043488, ECO:0000269\|PubMed:16678097}.
Subcellular location:		Cell junction, tight junction {ECO:0000269\|PubMed:16043488}. Note=Localized on the cell surface. May act as a transmembrane protein.
Tissue specificity:		Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta. {ECO:0000269\|PubMed:11257124}.
Domain:		The coiled coil domain interacts directly with the BAR domain of ARHGAP17. {ECO:0000269\|PubMed:16678097}.
Domain:		The angiostatin binding domain (871-1005) allows the binding to angiostatin. {ECO:0000269\|PubMed:16678097}.
Ptm:		Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation. {ECO:0000269\|PubMed:22385262}.
Miscellaneous:		'Motus' means 'motility' in Latin.
Similarity:		Belongs to the angiomotin family. {ECO:0000305}.
Sequence caution:		Sequence=AAH94712.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};