PDBsum entry 7l4v

Transcription/DNA

PDB id: 7l4v

Contents

Protein chains

66 a.a.

DNA/RNA

Ligands

EDO ×5

Waters ×207

PDB id:

7l4v

Name:

Transcription/DNA

Title:

C-terminal bzip domain of human c/ebpbeta bound to DNA with consensus recognition with gt mismatch

Structure:

Ccaat/enhancer-binding protein beta. Chain: a, b. Synonym: c/ebp beta,liver activator protein,lap,liver-enriched inhibitory protein,lip,nuclear factor nf-il6,transcription factor 5, tcf-5. Engineered: yes. DNA strand 1. Chain: c. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cebpb, tcf5, pp9092. Expressed in: escherichia coli. Expression_system_taxid: 866768. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.75Å R-factor: 0.200 R-free: 0.221

Authors:

J.R.Horton,X.Cheng

Key ref:

J.Yang et al. (2021). Preferential cebp binding to t:g mismatches and incre c-To-T human somatic mutations.. Nucleic acids res, 49, 5084. PubMed id: 33877329

Date:

21-Dec-20 Release date: 03-Nov-21

Protein chains

P17676  (CEBPB_HUMAN) -  CCAAT/enhancer-binding protein beta from Homo sapiens

Seq: 345 a.a.

Struc: 66 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

DNA/RNA chains

A-G-G-A-T-T-G-T-G-C-A-A-T-A-T-A 16 bases

A-T-A-T-T-G-C-G-C-A-A-T-C-C-T-T 16 bases