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UniProt functional annotation for O43913 | ||
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| UniProt code: O43913. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. {ECO:0000269|PubMed:31160578}. |
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| Subunit: | |
Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. {ECO:0000269|PubMed:12909626}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:31160578}. Chromosome {ECO:0000269|PubMed:31160578}. |
| Tissue specificity: | |
Abundant in spleen, ovary, prostate, testis, and colon mucosa. {ECO:0000269|PubMed:9765232}. |
| Ptm: | |
Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. {ECO:0000269|PubMed:31160578}. |
| Miscellaneous: | |
[Isoform 2]: Does not interact with ORC2. {ECO:0000305}. |
| Similarity: | |
Belongs to the ORC5 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.