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UniProt functional annotation for P15090 | ||
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| UniProt code: P15090. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. {ECO:0000250|UniProtKB:P04117}. |
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| Subunit: | |
Monomer (PubMed:15357969, PubMed:17077479). Homodimer. Interacts with PPARG (By similarity). {ECO:0000250|UniProtKB:P04117, ECO:0000269|PubMed:15357969, ECO:0000269|PubMed:17077479}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250|UniProtKB:P04117}. Nucleus {ECO:0000250|UniProtKB:P04117}. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export. {ECO:0000250|UniProtKB:P04117}. |
| Domain: | |
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. |
| Similarity: | |
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.