PDBsum entry 7fx7

Lipid binding protein

PDB id: 7fx7

Contents

Protein chain

130 a.a.

Ligands

QLL

DMS

EDO

Waters ×196

PDB id:

7fx7

Name:

Lipid binding protein

Title:

Crystal structure of human fabp4 with binding site mutated to fabp5 in complex with 5-methylsulfanyl-2-[(4-phenylmethoxy-1h-indazol-3-yl) methylsulfanyl]pyrimidin-4-ol, i.E. Smiles n1c(c(cnc1scc1=nnc2c1c(occ1ccccc1)ccc2)sc)o with ic50=0.372 microm

Structure:

Fatty acid-binding protein, adipocyte. Chain: a. Synonym: adipocyte lipid-binding protein,albp,adipocyte-type fatty acid-binding protein,a-fabp,afabp,fatty acid-binding protein 4. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fabp4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.12Å R-factor: 0.171 R-free: 0.213

Authors:

A.Ehler,J.Benz,U.Obst,T.Lubbers,M.G.Rudolph

Key ref:

U.Obst et al. Crystal structure of a human fabp4 complex. To be published, . PubMed id: 40748031

Date:

27-Apr-23 Release date: 14-Jun-23

Protein chain

P15090  (FABP4_HUMAN) -  Fatty acid-binding protein, adipocyte from Homo sapiens

Seq: 132 a.a.

Struc: 130 a.a.*

* PDB and UniProt seqs differ at 8 residue positions (black crosses)